Scientists determine how precursors of gene-regulating small RNAs are sorted...
A team of scientists at Cold Spring Harbor Laboratory (CSHL) has determined a hierarchical set of criteria that explain how the molecular precursors of gene-regulating small RNAs are sorted by the...
View ArticleOvercoming taxane resistance in cancer
Taxanes, a group of cancer drugs that includes paclitaxel (Taxol®) and docetaxel (Taxotere®), have become front-line therapy for a variety of metastatic cancers. But as with many chemotherapy agents,...
View ArticleBiologists determine microRNA activity is suppressed in mouse ovum
Biologists at the University of Pennsylvania studying oocytes in mice, the immature egg cells necessary for sexual reproduction, have demonstrated an unusual behavior in microRNA, or miRNA, activity...
View ArticleThe impact of genomics
Working with worms may not be your average person’s idea of a good time, but for University of Toronto researcher Dr. Andrew Fraser, they are fascinating.
View ArticleWhy symptoms of schizophrenia emerge in young adulthood
In reports of two new studies, researchers led by Johns Hopkins say they have identified the mechanisms rooted in two anatomical brain abnormalities that may explain the onset of schizophrenia and the...
View ArticleResearchers provide proof in humans of RNA interference using targeted...
A California Institute of Technology (Caltech)-led team of researchers and clinicians has published the first proof that a targeted nanoparticle -- used as an experimental therapeutic and injected...
View ArticleRNA Interference Delivered Using Nanoparticles Hits Target in Human Patients
(PhysOrg.com) -- A multi-institutional team of researchers and clinicians has published the first proof that a targeted nanoparticle can traffic into tumors, deliver double-stranded small interfering...
View ArticleMultistage nanovector system provides sustained delivery of siRNA cancer...
New research by scientists at The University of Texas Health Science Center at Houston (UTHealth) and The University of Texas M. D. Anderson Cancer Center could make it easier for patients to use a...
View ArticleNovel RNA interference screening technique identifies possible path for...
Researchers at the University of Massachusetts Medical School report in the journal Nature Medicine on a cellular pathway in the deadly brain cancer malignant glioma, a pathway essential to the...
View ArticleTeam discovers a piece of the puzzle for individualized cancer therapy via...
In a major cancer-research breakthrough, researchers at the McGill University, Department of Biochemistry have discovered that a small segment of a protein that interacts with RNA can control the...
View ArticleStudy identifies proteins that modulate life span in worms
Researchers at the Stanford University School of Medicine have identified a new group of proteins involved in determining the life span of laboratory roundworms. Blocking the expression of one member...
View ArticleMessenger RNAs are regulated in far more ways than previously appreciated,...
One way of regulating protein levels in cells is to shorten the lifespan of messenger RNAs (mRNAs). These are intermediary molecules that are first copied from DNA in the cell's nucleus via a process...
View ArticleNew approach to Alzheimer's therapy
Researchers from the German Centre for Neurodegenerative Diseases and the Ludwig-Maximilians-Universitat in Munich have shown that the ADAM10 protein can inhibit the formation of beta-amyloid, which is...
View ArticleResearchers discover key protein involved in DNA repair
In a groundbreaking study, University of Toronto researchers including Professors Daniel Durocher, Anne-Claude Gingras and Frank Sicheri have uncovered a protein called OTUB1 that blocks DNA damage in...
View ArticleThe art of dividing: Researchers decode function and protein content of the...
A basic requirement for growth and life of a multicellular organism is the ability of its cells to divide. A protein complex, the so-called centrosome, plays a major role during cell division....
View ArticleNew study examines how bacteria acquire immunity
In a new study this week, Rice University scientists bring the latest tools of computational biology to bear in examining how the processes of natural selection and evolution influence the way bacteria...
View ArticleVirtual research institute needed to unlock RNA's promise
A Europe-wide network of labs focusing on RNA research is needed to make the most of RNA's high potential for treating a wide range of diseases. The recommendation for this virtual research institute...
View ArticleTurning the cancer genes off
In the past 40 years, scientists have learned a great deal about how cells become cancerous. Some of that knowledge has translated to new treatments, but most of the time doctors are forced to rely on...
View ArticleMicroRNA-TP53 circuit connected to chronic lymphocytic leukemia
The interplay between a major tumor-suppressing gene, a truncated chromosome and two sets of microRNAs provides a molecular basis for explaining the less aggressive form of chronic lymphocytic...
View ArticleBiologists' favorite worm gets viruses
A workhorse of modern biology is sick, and scientists couldn't be happier.
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